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Journal of Family and Reproductive Health، جلد ۳، شماره ۴، صفحات ۱۰۱-۱۰۸
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عنوان انگلیسی Chronic Stress and Limbic-Hypothalamopituitary-Adrenal Axis (LHPA) Response in Female Reproductive system
چکیده انگلیسی مقاله The hypothalamo-pituitary-adrenocortical (HPA) axis is a critical adaptive system that maximizes survival potential in the face of physical or psychological challenge. The principal end products of the HPA axis, glucocorticoid hormones, act on multiple organ systems, including the brain, to maintain homeostatic balance. The brain is a target of stress, and the hippocampus is the first brain region, besides the hypothalamus, to be recognized as a target of glucocorticoids. These anatomical areas in brain are limbic system, and in particular the hippocampus, medial prefrontal cortex (mPFC) and amigdal that have multiple control points in regulation of the hypothalamic–pituitary–adrenal (HPA) axis. The studies show the prefrontal cortex (PFC) plays an important role in the regulation of stress-induced hypothalamic–pituitary–adrenal (HPA) activity and regulation of gonadal function in men and women is under the control of the HPA. This regulation is complex and sex steroids are important regulators of GnRH and gonadotropin release through classic feedback mechanisms in the hypothalamus and pituitary gland. Chronic stress can have a deleterious effect on the reproductive axis that, for females, is manifested in reduced pulsatile gonadotropin secretion and increased incidence of ovulatory abnormalities and infertility. The limbic–hypothalamic–pituitary–adrenal (LHPA) axis suggests a functional role for gonadal steroids in the regulation of a female’s response to stress.
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نویسندگان مقاله فریده ظفری زنگنه | farideh zafari zangeneh
vali-e-asr reproductive health research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه سرمست شوشتری | fatemeh sarmast shooshtary
medical faculty, shaheed beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://jfrh.tums.ac.ir/index.php/jfrh/article/view/77
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Review Articles
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