این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۷، شماره ۲، صفحات ۱۷۹-۱۸۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluating Serum Levels of IL-33, IL-36, IL-37 and Gene Expression of IL-37 in Patients with Psoriasis Vulgaris
چکیده انگلیسی مقاله Serum levels of interleukin (IL)-33, IL-36 and IL-37 have been reported to be up-regulated in various T helper (Th)1/Th17 mediated autoimmune/inflammatory diseases. Although IL-33 and IL-36 expression are increased in skin lesions of patients with psoriasis, their serum levels in such patients have not yet been adequately studied. We aimed to evaluate serum level of IL-33, IL-36 and IL-37 cytokines and IL-37 gene expression in patients with autoimmune/inflammatory disease of psoriasis and to explore their correlation with disease severity. Such evaluation further clarifies disease pathogenesis and may be utilized in clinical practice. 47 patients with psoriasis vulgaris and 47 healthy individuals were included. Serum IL-33, IL-36 and IL-37 levels were measured by Elisa and gene expression of IL-37 measured by real time PCR in all participants. The disease activity was assessed by the psoriasis area and severity index (PASI). Linear Correlation between interleukin measures and PASI score was calculated. Also sensitivity and specificity of such measurements were determined. Serum IL-36 and 37 levels in patients with psoriasis vulgaris were significantly higher than those in healthy controls and positively correlated with disease activity (PASI score). Serum IL-33 levels in patients were equal to those in healthy controls but positively correlated with disease activity. Serum IL-36 levels were significantly higher than serum IL-33 levels. Gene expression of IL-37 levels in patients were higher than healthy controls but was not correlated with disease activity. Serum IL-36 and IL-37 levels are generally increased in psoriasis vulgaris and correlated with disease severity. Therefore, serum IL-36 and IL-37 levels may be markers of treatment and diagnosis of psoriasis.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Mojtaba Sehat
Autoimmune Research Centre, Kashan University of Medical Sciences, Kashan, Iran


| Rezvan Talaei
Students’ Research Centre, Kashan University of Medical Sciences, Kashan, Iran


| Ehsan Dadgostar
Department of Immunology, Medicine School, Baqiyatallah University of Medical Sciences, Tehran, Iran and Nephrology and Urology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Hassan Nikoueinejad
Trauma Research Centre, Kashan University of Medical Sciences, Kashan, Iran


| Hossein Akbari


نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/1434
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/89/article-89-584809.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article(s)
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات