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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۷، شماره ۲، صفحات ۱۵۱-۱۵۷
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عنوان انگلیسی Association of Regulatory T Cells with Diabetes Type-1 and Its Renal and Vascular Complications Based on the Expression of Forkhead Box Protein P3 (FoxP3), Helios and Neurophilin-1
چکیده انگلیسی مقاله In recent years, it has been recognized that regulatory T cells (Tregs) play a critical role in maintaining immune tolerance. Moreover, the expression of two markers named Helios and neurophilin-1 (NRP-1) has been highlighted in such cells. Helios, an intracellular transcription marker, largely differentiates twomost operative sub group of Tregs, namely naturally occurring (nTreg) and induced (iTreg) Tregs, and NRP-1 is reckoned as a membranous activity marker of Tregs. We aimed to count peripheral mononuclear cells expressing such markers in a group of type 1 diabetes patients to elucidate the possible role of Tregs in the pathogenesis of such disease and its complications. Blood samples from 61 adult patients with type 1 diabetes and 61 sex and age-matched healthy controls were tested to count two types of Tregs, namely naturally occurring and inducible types, according to the expression of cell surface markers of CD4/CD25/CD47–FITC/PE/APC and intracellular markers of FoxP3/Helios–PE-CY5/eFlour450 by flow cytometry, respectively.We also investigated the relation between expression of such markers with HbA1c, urine albumin/creatinine ratio (UACR), and common carotid intima thickness (CIMT). The circulatory frequency of both Helios+ and Helios- T-cells were significantly decreased in patients compared to those in healthy controls ( p < 0.001). There was also a significant decrease in circulatory frequency of Helios+ NRP-1+ and Helios- NRP-1+ cells in the patients compared to controls ( p =0.029). According to expression of Helios and NRP-1 markers, the number and function of both Tregs were decreased in diabetic patients. Moreover, the neurophilin expression was inversely associated with complications of type 1 diabetes.
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نویسندگان مقاله | Tahereh Khamechian
Department of Pathology, Kashan University of Medical Sciences, Kashan, Iran


| Behnaz Irandoust
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran


| Hanieh Mohammadi
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Hassan Nikoueinejad
Department of Biostatistics and Public Health, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran


| Hossein Akbari


نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/1353
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/89/article-89-584806.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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