| چکیده انگلیسی مقاله |
Allergic sensitization to inhalant allergens could be considered as a predictor in allergic diseases. The objective of this study was to assess IgE-mediated sensitization to inhalant allergens in allergic and non-allergic adults as well as the evaluation of its association with allergic diseases. This cross-sectional study was conducted from 2013 to 2016 in 604 allergic and 102 non-allergic adults selected from blood donor volunteers in Tehran, Iran. After taking informed consent, a standard questionnaire was filled to determine asthma, allergic rhinitis and/or conjunctivitis and atopic dermatitis in participants. Specific IgE assay to common inhalant allergens was performed for all subjects. Logistic regression analysis was used to evaluate the impact of IgE sensitization on allergic diseases. A total of 371(61.4%) allergic subjects and 41(40.2%) non-allergic patients were males. The weeds (especially saltwort) and grasses (particularly meadow fescue and ryegrass) were identified as the most common inhalant allergens. The prevalence of IgE sensitization to trees, weeds, and grasses was higher in subjects with allergic rhino-conjunctivitis and trees sensitization was a significant factor in them [OR=2.32, 95% CI (1.58-3.41)]. IgE sensitization to any inhalant allergens could be a predictor for allergic rhinitis, conjunctivitis and rhino-conjunctivitis in adults [OR=2.20, 95% CI (1.54-3.15], [OR=1.81, 95% CI (1.28-2.54)] and [OR=2.55, 95% CI (1.72-3.78)], respectively. With an increase in the sum of specific IgE concentrations, the prevalence of allergic conjunctivitis and rhino-conjunctivitis also increased. Our results showed the association between positive specific IgE and its concentration with some allergic diseases which could help physicians to prevent such diseases by recognizing and treating them, particularly in individuals with a positive family history of allergic diseases. |
| نویسندگان مقاله |
| Raheleh Shokouhi Shoormasti
Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Reza Fazlollahi
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
| Anoshirvan Kazemnejad
Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Behnoosh Tayebi
Hematology and Blood Banking Department, Allied Health School Medical, Tehran University of Medical Sciences, Tehran, Iran AND Blood Transfusion Organization Research Center, Tehran, Iran
| Fatemeh Nadali
Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
| Maryam Sharif Shoushtari
Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Shamim Khandan Alamdari
Blood Transfusion Organization Research Center, Tehran, Iran
| Majid Moslemi
Department of Immunology and Allergy, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
| Masoud Movehdi
Associated Centers for Molecular Allergology, CAAM, Rome, Italy
| Adriano Mari
Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Zahra Pourpak
Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology and Allergy, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
| Mostafa Moin
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