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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۷، شماره ۱، صفحات ۳۹-۴۶
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عنوان انگلیسی Regulatory Effect of Xiaoqinglong Decoction on Thymic Stromal Lymphopoietin (TSLP) Inflammation Promoter in Mice with Cold Asthma
چکیده انگلیسی مقاله Allergic asthma is a complex and chronic inflammatory airway disease. The thymic stromal lymphopoietin (TSLP) signaling pathway plays an important role in asthma. Xiaoqinglong Decoction (XQL) is the first choice to treat cold asthma in clinical settings. In this study, the role of the TSLP pathway in the onset of asthma and the protective mechanism of XQL were investigated. A total of 50 female mice were randomly divided into the following groups: the blank group (A), the model group (B), the XQL group (C), the dexamethasone group (D), and the XQL + dexamethasone group (E). Asthma was induced with ovalbumin, and corresponding drug intervention was carried out for 7 days, after which serum and lung tissue end points were analyzed. Serum interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor κB (NF-κB), and TSLP levels were higher in group B than in group A ( p < 0.05). However these levels were lower in group C and D than in group B ( p < 0.05), and there was no significant difference between groups C and D ( p >0.05). Interestingly, these end points were significantly lower in group E than in groups C and D ( p < 0.05). Regarding pathologic changes, the inflammatory infiltrate in the lungs of groups C, D, and E was lower than that of group B, especially in group E. We conclude that the TSLP pathway plays an important role in the course of asthma, and can be used as an important target for asthma treatment; XQL may play a role in reducing inflammation and relieving asthma by regulating the TSLP signaling pathway.
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نویسندگان مقاله گویهوا song | guihua song
department of pediatrics, the first affiliated hospital of henan university of traditional chinese medicine, zhengzhou, china


یان زانگ | yan zhang
department of pediatrics, the first affiliated hospital of henan university of traditional chinese medicine, zhengzhou, china


kun zhao | kun zhao
department of pediatrics, the first affiliated hospital of henan university of traditional chinese medicine, zhengzhou, china


mengmeng سون | mengmeng sun
department of pediatrics, the first affiliated hospital of henan university of traditional chinese medicine, zhengzhou, china


pengju چنگ | pengju cheng
department of pediatrics, the first affiliated hospital of henan university of traditional chinese medicine, zhengzhou, china


جینگ ونگ | jing wang


نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/1410
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/89/article-89-573578.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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