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Iranian Journal of Allergy, Asthma and Immunology، جلد ۲، شماره ۲، صفحات ۶۹-۷۴
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عنوان انگلیسی TWO RELATED CASES OF PRIMARY COMPLEMENT DEFICIENCY
چکیده انگلیسی مقاله Primary complement deficiencies are rare and two related patients are reported here. The first patient is a 41- year- old man with eighteen episodes of pneumo¬coccal meningitis and other purulent infections. The serum C3 level was checked at three separate times, showing that this was a primary C3 deficient case; other immunological tests were however normal. This patient now takes prophylactic antibiotics and the meningitis has not recurred, but he does have glomerulone¬phritis. The second case is a 40 - year-old woman with repeated episodes of orofacial and laryngeal edema and dyspnea. The serum C1INH levels were 4.3 to 7 mg/dL which were very low compared with normal healthy subjects (C,INH was 40-50 mg/dL in ten normal controls) and C4 was lower than normal but other immunological tests were normal. Other causes of angioedema such as lymphoproliferative disorders were excluded. She had hereditary angioedema with¬out a family background. The condition may be due to genetic mutation. The angioedema was controlled with Danazol and Stanasol. As our patients are re¬lated, this may suggest a genetic relationship between these two disorders.
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نویسندگان مقاله a فرهودی | a farhoudi


نسرین بازرگان | nasrin bazargan


zaiirn پورپاک | zaiirn pourpak


مریم محمودی | maryam mahmoudi


نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/36
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