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Iranian Journal of Allergy, Asthma and Immunology، جلد ۳، شماره ۱، صفحات ۳۱-۳۵
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عنوان انگلیسی Mortality in Primary Immunodeficient Patients, Registered in Iranian Primary Immunodeficiency Registry
چکیده انگلیسی مقاله Primary immunodeficiencies (PID) are a group of disorders, characterized by an unusual susceptibility to infections. Delay in diagnosis results in increased morbidity and mortality in affected patients. The purpose of this study was to determine the mortality rate of Iranian immunodeficient patients referred to Children Medical Center Hospital affiliated to Tehran University of Medical Sciences over a period of 20 years. In this study, records of 235 (146 males, 89 females) patients with immunodeficiency who were diagnosed and followed in our center, during 22 years period (1979-2001) were reviewed. The diagnosis of immunodeficiency was based on the standard criteria. The cause of death was determined by review of death certificates. Antibody deficiency was the most common diagnosis made in our patients. The overall five-year survival rate was 22.7% in our studied patient group; this was greatest in antibody deficiency. During the 22 year period of study, 32 patients died. As some of the patients could not be located, the true mortality rate ranged between 13.6% and 17.5%. The main leading cause of death were lower respiratory tract involvement in 14 cases (44%). The most common pathogenic microorganisms causing fatal infections were psudomonas and staphylococcus in 9 cases (28.1%) followed by E. coli in 7 (21.9%), tuberculosis in 13 (40.6%) and salmonella in 1 (3.1%). Based on our study, delay in diagnosis in patients with PID results in tissue and organ damage and several complications. Mortality and morbidity are increased in undiagnosed patients.
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نویسندگان مقاله بهرام میر سعید قاضی | bahram mir saeid ghazi


اصغر آقامحمدی | asghar aghamohammadi


علی کوهی | ali kouhi


ابوالحسن فرهودی | abolhassan farhoudi


مصطفی معین | mostafa moin


نیما رضایی | nima rezaei


پریسا شهریار دوست | parisa shahriar doost


مسعود موحدی | masoud movahedi


محمد قره گوزلو | mohammad gharagozlou


زهرا پورپاک | zahra pourpak


صبا عرشی | saba arshi


فرشته یزدانی | fereshteh yazdani


لیدا عطارد | lida atarod


ایرج محمد زاده | iraj mohammad zadeh


نسرین بازرگان | nasrin bazargan


عاکفه احمدی افشار | akefeh ahmadi afshar


مریم محمودی | maryam mahmoudi


امیر طاهایی | amir tahaei


نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/65
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