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Iranian Journal of Allergy, Asthma and Immunology، جلد ۶، شماره ۳، صفحات ۱۳۷-۱۴۲
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عنوان انگلیسی HLA Class II Allele and Haplotype Frequencies in Iranian Patients with Leukemia
چکیده انگلیسی مقاله Previous studies demonstrated significant differences in a number of HLA allele frequencies in leukemia patients and normal subjects. In this study, we have analyzed HLA class II alleles and haplotypes in 110 leukemia patients (60 acute myelogenous leukemia "AML", 50 chronic myelogenous leukemia"CML") and 180 unrelated normal subjects. Blood samples were collected from all of the patients and control subjects. DNA was extracted by salting out method and HLA typing was performed using PCR-SSP method. Significant positive association with AML was obtained for HLA-DRB1*11allele (35% vs. 24.7%, P=0.033). Two alleles including HLA-DRB4 and -DQB1*0303 were significantly less frequent in AML patients than in controls. HLA-DQB1*0303 allele was never observed in CML patients compared with allele frequency in controls (4.2%). According to haplotype analysis, HLA-DRB1*0101/DQA1*0104/-DQB1*0501 frequencies were significantly higher and -DRB1*16/-DQA1*01021/-DQB1*0501 frequencies were significantly lower in CML patients than in controls .In conclusion it is suggested that HLA-DRB1*16 allele and HLA-DRB1*15/-DQA1*0103/-DQB1*06011 and -DRB1*16/-DQA1*01021/-DQB1*0501 haplotypes predispose individuals to AML and HLA-DRB4 allele predispose to CML. Future studies are needed to confirm these results and establish the role of these associations in AML and CML.
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نویسندگان مقاله فریده خسروی | farideh khosravi


علی اکبر امیرزرگر | aliakbar amirzargar


عبدالفتاح عبدالفتاح | abdolfatah sarafnejad


محمد حسین نیکنام | mohammad hossein nicknam


کامران علی مقدم | kamran alimoghadam


سعید دیانت | saied dianat


قاسم سلگی | ghasem solgi


بهروز نیک بین | behrouz nikbin


نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/177
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