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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۰، شماره ۱، صفحات ۱۱-۱۹
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عنوان انگلیسی HLA-DR1, Circulating Th1/Th2 Cytokines and Immunological Homunculus in Coronary Atherosclerosis
چکیده انگلیسی مقاله Coronary atherosclerotic disease is one of the most endangering health disorder worldwide. This study was designed to investigate the correlation between HLA-DRβ1 alleles and circulating Th1/Th2 type cytokines in coronary atherosclerosis. By Elisa, Th1/Th2 type cytokines were determined in serum samples of 31 subjects with unstable angina, 27 subjects with chronic stable angina and 24 individuals as normal control. By SSP-PCR, more than 100 alleles of HLA-DRB1 were typed in 24 subjects who had skewed serum levels of Th1/Th2 type cytokines. Lipid profiles were determined by the routine methods of clinical laboratory in all subjects. The mean serum concentration of IL-10 in normal control subjects was higher in comparison to the patient groups.0.33±0.59 pg/ml versus 0.064±0.3 pg/ml in unstable angina pectoris group (p< 0.028) and 0.22±0.6 pg/ml in chronic stable subjects. There was no statistically significant difference among the groups in serum levels of other desired cytokines (IFN-γ, IL-4). 33.33% of normal control subjects were HLA-DR16 positive whereas none of the subjects with chronic stable angina or individuals with unstable angina pectoris was positive for this antigen. The mean concentration of serum LDL-cholesterol in normal control group was high 142.046±35.40 (pg/ml). This preliminary study shows that the atherogenic effect of the LDL- cholesterol may be dampened by HDL-cholesterol through anti inflammatory cytokine IL-10 and HLA-DR16, a phenomenon interpretable via immunological homunculus theory.
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نویسندگان مقاله امراله مصطفی زاده | amrollah mostafazadeh
cellular and molecular biology research center, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

مهرداد ساروی | mehrdad saravi
department of cardiology, ayatollah rohani hospital, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

هاله اخوان نیاکی | haleh akhavan niaki
cellular and molecular biology research center, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

jos drabbels | jos drabbels
department of immunohematology and blood transfusion, leiden university medical center, leiden, netherlands


حاجی محمد قلی پور | haji mohammad gholipour
department of cardiology, ayatollah rohani hospital, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

میلاد میناگر | milad minagar
department of cardiology, ayatollah rohani hospital, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

عزت اله موسوی | ezatola mosavi
department of microbiology and immunology, faculty of medicine, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

فرزاد جلالی | farzad jalali
department of cardiology, ayatollah rohani hospital, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

علی بیژنی | ali bijani
non- communicable pediatrics diseases research center, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/287
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