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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۱، شماره ۳، صفحات ۲۲۴-۲۲۹
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عنوان انگلیسی Association of single nucleotide polymorphisms in the human tumor necrosis factor-α and interleukin 1-β genes in patients with pre-eclampsia.
چکیده انگلیسی مقاله Pre-eclampsia is a pregnancy-specific syndrome that may be dangerous especially to the fetus. Different cytokines have been found to be elevated in women with pre-eclampsia and may have possible roles in the development of this disorder. Alleles of the interleukin-l-beta (IL-lβ) and tumor necrosis factor alpha (TNF-α) genes are associated with pr-eeclampsia in several studies in different populations. The aim of the present study was to investigate the relationship between IL-lβ (C+3954T) and TNF-α (G-308A) gene polymorphisms with pre- eclampsia in north east of Iran (Khorasan province). This study included 54 diagnosed patients with pre-eclampsia and 50 normal pregnant women as control group. DNA was extracted from peripheral blood and the polymorphisms were determined by PCR-RFLP method. Data was analyzed using chi-square and Fisher’s exact tests. There was significant association between TNF-α (G-308A) genotype and pre-eclampsia (p=0.001) but we did not find any significant association between IL-lβ (C+3954T) genotype and pre-eclampsia (p=0.39). The present study might suggest a role for TNF-α in the development of pre-eclampsia; however, IL-lβ (C+3954T) polymorphism
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نویسندگان مقاله فرناز mohajertehran | farnaz mohajertehran
department of genetics, ghaem hospital, university of medical sciences, mashhad, iran.


جلیل توکل افشاری | jalil tavakkol afshari
department of immunogenetic amp;amp; tissue culture, immunology research center, bu ali research institute, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

زهرا رضایی یزدی | zahra rezaieyazdi
rheumatic diseases research center, ghaem hospital, faculty of medicine, university of medical sciences, mashhad, iran


نیره قمیان | nayereh ghomian
women health research center, imam reza hospital, faculty of medicine, university of medical sciences, mashhad, iran
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/559
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