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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۱، شماره ۴، صفحات ۳۱۶-۳۲۳
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عنوان انگلیسی Effect of Hedera helix on lung histopathology in chronic asthma.
چکیده انگلیسی مقاله Hedera helix is widely used to treat bronchial asthma for many years. However, effects of this herb on lung histopathology is still far from clear. We aimed to determine the effect of oral administration of Hedera helix on lung histopathology in a murine model of chronic asthma. BALB/c mice were divided into four groups; I (Placebo), II (Hedera helix), III (Dexamethasone) and IV (Control). All mice except controls were sensitized and challenged with ovalbumin. Then, mice in group I received saline, group II 100 mg/kg Hedera helix and group III 1 mg/kg dexamethasone via orogastic gavage once daily for one week. Airway histopathology was evaluated by using light and electron microscopy in all groups. Goblet cell numbers and thicknesses of basement membrane were found significantly lower in group II, but there was no statistically significant difference in terms of number of mast cells, thicknesses of epithelium and subepithelial smooth muscle layers between group I and II. When Hedera helix and dexamethasone groups were compared with each other, thickness of epithelium, subepithelial muscle layers, number of mast cells and goblet cells of group III were significantly ameliorated when compared with the group II. Although Hedera helix administration reduced only goblet cell counts and the thicknesses of basement membrane in the asthmatic airways, dexamethasone ameliorated all histopathologic parameters except thickness of basement membrane better than Hedera helix.
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نویسندگان مقاله ارزو babayigit hocaoglu | arzu babayigit hocaoglu
department of pediatrics, dokuz eylul university hospital, division of allergy, balcova, izmir, turkey


ozkan خرامان | ozkan karaman
department of pediatrics, dokuz eylul university hospital, division of allergy, balcova, izmir, turkey


دویگو olmez erge | duygu olmez erge
department of pediatrics, dokuz eylul university hospital, division of allergy, balcova, izmir, turkey


guven erbil | guven erbil
department of histology and embriology, dokuz eylul university hospital, balcova, izmir, turkey


عثمان یلماز | osman yilmaz
department of multidisciplinary animal laboratory balcova, dokuz eylul university hospital, izmir, turkey


bijen kivcak | bijen kivcak
department of pharmacognosy, ege university, faculty of pharmacy, bornova, izmir, turkey


h alper bagriyanik | h alper bagriyanik
department of histology and embriology, dokuz eylul university hospital, balcova, izmir, turkey


nevin uzuner | nevin uzuner
department of pediatrics, dokuz eylul university hospital, division of allergy, balcova, izmir, turkey
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/546
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