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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۲، شماره ۴، صفحات ۳۴۵-۳۵۱
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عنوان انگلیسی Gene polymorphisms of TNF-α and IL-1β are not associated with generalized aggressive periodontitis in an Iranian subpopulation.
چکیده انگلیسی مقاله Cytokines play a part in pathogenesis of periodontitis via inflammation phenomenon. Aggressive periodontitis (AgP) is a multifactorial disease resulting in rapid tooth loss due to severe destruction of tooth supporting apparatus. Recently, researchers have focused on genetic susceptibility of periodontitis through investigating the gene variations of cytokines and other components of immune response. In this study we analyzed single nucleotide polymorphism (SNP) of two cytokines in association with AgP in an Iranian-Khorasani population; Interleukin-1 beta (IL-1β) +3954 C/T and Tumor Necrosis Factor alpha (TNF- α) -308 G/A. From arm vein of patients (n=58) and periodontally healthy individuals (n=60) blood sample was obtained and the DNA was extracted. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) procedure was performed to recognize the SNPs. X2 test was used to determine the statistically significant differences between the two groups. The frequency of genotypes and alleles had no significant differences between patients and control groups. The distributions were as follows. IL-1β +3954: CT, CC and TT genotypes in patients were 39.6%, 60.4% and 0.0% and in controls were 41.7%, 50% and 8.3%, respectively. TNF-α -308: GA, GG and AA genotypes in patients were 44.8%, 41.4% and 13.8% and in controls were 46.7%, 50% and 3.3%, respectively. This investigation do not substantiates the role of IL-1β +3954 and TNF-α -308 polymorphisms, separately, as risk determinants for AgP in Iranian population. Further research based on all components of immune response, is needed to corroborate the genetic susceptibility of AgP.
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نویسندگان مقاله احمد رضا عبادیان | ahmad reza ebadian
department of periodontology, school of dentistry, mashhad university of medical science, mashhad, iran and department of immunology, bu-ali research institute, mashhad university of medical science, mashhad, iran


مهرداد رادور | mehrdad radvar
department of periodontology, school of dentistry, mashhad university of medical science, mashhad, iran


جلیل توکل افشاری | jalil tavakkol afshari
department of immunology, bu-ali research institute, mashhad university of medical science, mashhad, iran


ناصر سرگلزایی | naser sargolzaee
department of periodontology, school of dentistry, mashhad university of medical science, mashhad, iran


اعظم بروک | azam brook
department of immunology, bu-ali research institute, mashhad university of medical science, mashhad, iran


rashiin گنجعلی | rashiin ganjali
department of immunology, bu-ali research institute, mashhad university of medical science, mashhad, iran


محمود تمیزی | mahmood tamizi
department of periodontology, school of dentistry, mashhad university of medical science, mashhad, iran


حمید رضا عرب | hamid reza arab
department of periodontology, school of dentistry, mashhad university of medical science, mashhad, iran
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/493
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