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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۲، صفحات ۱۵۸-۱۶۷
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عنوان انگلیسی The Effect of IL-22 and IL-28 in Induction of Type 1 Regulatory T (Tr1) Cells.
چکیده انگلیسی مقاله Cytokines have been introduced as critical inducers in the development of Th subpopulations.Cytokines like IL-10 are involved in inducing regulatory T cells such as Type 1 regulatory T (Tr1) cells cells. IL-22 is a member of IL-10 family of cytokines, and IL-28A is a member of IFN-γ family. In this study, cord blood mononuclear cells (CBMC) from normal healthy individuals were isolated by Ficoll and then naïve T cells were purified by CD4+CD25+ Regulatory T cell Isolation kit. The effect of these two cytokines on production of IL-5, TGF-β, IL-10, IL-4 and IFN-γ cytokines from cord blood T cells was investigated to identify Tr1 cells as well as Th1 and Th2 polarization. Flow cytometric analysis showed that IL-28A and IL-22 were not effective in expression of IL-5 and TGF-β either alone or in synergy, but in view of IL-10, IL-4 and IFN-γ, the results showed that IL-22 increased IL-10 and IL-4 but had a decreasing effect on IFN-γ. The results showed that IL-28A was not effective in increasing or decreasing the level of IL-10, IL-4 and IFN-γ. Therefore, according to these results, IL-22 and IL-28A were not effective in inducing Tr1 cells.
کلیدواژه‌های انگلیسی مقاله Cord blood,IL-22,IL-28A,Polarization,Tr1 cells
نویسندگان مقاله جواد آراسته | javad arasteh
department of biology, faculty of basic sciences, islamic azad university central tehran branch, tehran, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

معصومه ابتکار | massoumeh ebtekar
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

زهرا پورپاک | zahra pourpak
immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی اکبر پورفتح الله | ali akbar pourfatollah
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

زهیر محمد حسن | zuhair mohammad hassan
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

غلام علی کاردار | gholam ali kardar
immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

احد زارع | ahad zare
immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شیوا ثقفی | shiva saghafi
immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

agheel تبار ملا حسن | agheel tabar molla hassan
department of immunology, faculty of medical sciences,, islamic azad university babol branch, babol, iran.

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/398
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