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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۳، صفحات ۳۱۳-۳۲۰
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عنوان انگلیسی The Opposite Effects of DNA and Protein Components of Listeria Monocytogenes and Toxoplasma gondii on Immunologic Characteristics of Dendritic Cells
چکیده انگلیسی مقاله The innate immune system utilizes pattern recognition receptors (PRRs) to recognize microbes. Pathogens contain various molecules with diverse effects on immune response. In this study, we evaluated the effect of DNA and protein components derived from two intracellular microorganisms including Listeria monocytogenes (L.monocytogenes) and Toxoplasma gondii (T. gondii) on dendritic cells (DCs) activation and ensuing adaptive immune responses.DNA and protein components of L. monocytogenes and T. gondii were prepared using relevant kits. DNA and protein components of these two pathogens were added to immature DCs (iDCs). Subsequently, co-stimulatory expression and cytokine production by DCs were measured. Finally, we evaluated the stimulatory capacity of mature DCs (mDCs) in DC-T cells co-culture.The results showed that protein matured-DCs produced higher level of IL (Interleukin)-12p70. There was also a significant increase in Interferon-Gamma (IFN-γ) production and proliferative capacity in T cells co- cultured with protein matured-DCs. On the other hand, DNA matured-DCs produced significantly higher amounts of Transforming growth factor-beta (TGF-β).Collectively, these results imply a regulatory nature for DNA and potent stimulatory character for protein components of these two intracellular microorganisms.
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نویسندگان مقاله رضا میرزایی | reza mirzaei
department of immunology, school of medicine, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سمانه عرب | samaneh arab
department of molecular medicine, school of advanced medical technologies, tehran university of medical science, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

معصومه معتمدی | masoumeh motamedi
razi herbal medicines research center, lorestan university of medical sciences, khorramabad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی لرستان (Lorestan university of medical sciences)

افشین عماری | afshin amari
department of immunology, ahvaz jondishapur university of medical sciences, iran


جمشید حاجتی | jamshid hadjati
department of immunology, school of medicine, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/573
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زبان مقاله منتشر شده en
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