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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۳، صفحات ۳۰۶-۳۱۲
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عنوان انگلیسی Association of HLA-DRB1 Alleles with Ulcerative Colitis in the City of Kerman, South Eastern Iran
چکیده انگلیسی مقاله The association of HLA class II genes with ulcerative colitis (UC) as an autoimmune disease has been investigated for several years. However, factors responsible for genetic predisposition of this disease have so far not been clearly understood. In this study, for the first time, we aimed to investigate the association between HLA-DRB1 types and UC in the population of Kerman, a city southeast Iran. HLA typing was performed among 85 UC patients and 95 healthy controls using PCRamplification, employing sequence specific primers (PCR-SSP). The DRB1 frequencies were determined in the patients and controls. HLA-DRB1*04 was negatively associated with UC. Furthermore, HLA-DRB1*13 was significantly associated with severity of the disease (p=0.01) among UC patients. This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective role of HLA-DRB1*04 against the disease in people of Kerman.
کلیدواژه‌های انگلیسی مقاله HLA-DRB1,IBD,Iran,PCR-SSP,Ulcerative colitis
نویسندگان مقاله مژگان محمدی | mojgan mohammadi
physiology research center, institute of neuropharmacology, kerman universityof medical sciences, kerman, iran and department of immunology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مریم راستین | maryam rastin
department of immunology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

هوشنگ رفعت پناه | houshang rafatpanah
inflammation and inflammatory diseases research center,school of medicine, mashhad university of medical sciences,mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

هاله عبدلی سرشکی | haleh abdoli sereshki
physiology research center, institute of neuropharmacology, kerman universityof medical sciences, kerman, iran


محمدجواد زاهدی | mohammadjavad zahedi
department of gastroenterology, afzalipour hospital, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

امین رضا نیک پور | aminreza nikpoor
department of immunology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمدرضا بانشی | mohammadreza baneshi
modelling in health research centre, institute of future studies in health, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

محمدمهدی حیاتبخش | mohammadmahdi hayatbakhsh
department of gastroenterology, afzalipour hospital, kerman university of medical sciences, kerman, iran and gastroenterology and hepatology research center, institute of basic and clinical physiology sciences, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/572
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