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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۳، صفحات ۲۹۸-۳۰۵
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عنوان انگلیسی Evaluation of Soluble Human Leukocyte Antigen-G (sHLA-G) Isoforms and Regulatory T Cells in Relapsing-Remitting Multiple Sclerosis
چکیده انگلیسی مقاله Soluble forms of nonclassical human leukocyte antigen (HLA)-G have recently been suggested as immunomodulatory factors in multiple sclerosis (MS). HLA-G inhibits the effecter function of T cells and natural killer (NK) cells. Also regulatory T cells (Treg) are considered as pivotal players in MS pathogenesis. Thus, we aimed to evaluate the presence of HLA-G molecules and Treg cells in Relapsing-Remitting Multiple Sclerosis (RRMS) patients and compare it to healthy controls.Patients with RRMS (n=205, mean age=31.32±8.53) and healthy subjects (n=205, mean age=32.2±7.48) were studied. The patients subgrouped to untreated and treated with Interferon beta. Then sHLA-G levels (sHLA-G1 and sHLA-G5) were measured using ELISA method. Treg (CD4+CD25+ Foxp3+) cells in patients who had sHLA-G>10 U/ml were characterized by using flow cytometry.Our data showed that there was no significant differences between RRMS patients and healthy controls in sHLA-G concentration (p>0.05). Treg cell frequencies were higher in the patients who had sHLA-G >10 U/ml compared to healthy subjects (p< 0.05).Collectively, there was significant correlation between sHLA-G and frequency of Treg cells in treated RRMS patients and healthy individuals. It seems that high level sHLA-G has been instrumental in raising frequency of Treg cells in treated patients and could be associated with remission of MS disease.
کلیدواژه‌های انگلیسی مقاله Multiple sclerosis,Regulatory T cells,sHLA-G
نویسندگان مقاله فرشته آل صاحب فصول | fereshteh alsahebfosoul
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

احمد زواران حسینی | ahmad zavaran hosseini
department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

رسول صالحی | rasoul salehi
department of molecular biology faculty of medicine, isfahan university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مسعود اعتمادی فر | masood etemadifar
neurology department, faculty of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نفیسه اسماعیل | nafiseh esmaeil
department of immunology, faculty of medicine, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

اعظم جمشیدیان | azam jamshidian
department of immunology, faculty of medicine, shahrekord university of medical sciences, shahrekord, iran.
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/571
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