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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۳، صفحات ۲۸۷-۲۹۱
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عنوان انگلیسی Association of Tumor Necrosis Factor Alpha 308 G/A Polymorphism with Asthma in Pakistani Population
چکیده انگلیسی مقاله Asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. The role of tumor necrosis factor- α (TNF-α) in asthma is unclear in Pakistani population. The aim of this study was to assess the relationship between TNF-α -308 polymorphism and asthma.Polymorphism of TNF-α (G-308-A locus; rs 1800629) in 329 asthmatic patients and 151 healthy controls was evaluated. DNA was prepared from blood samples of cases and controls. Samples were genotyped for TNF-α 308 G/A polymorphism.There was no significant difference in the frequency of GG (OR 1.049 with 95% CI 0.68-1.63) and GA (OR 0.987 with 95% CI 0.64-1.53) genotypes of TNF-α-308. The AA genotype was absent in cases and only one AA genotype was observed in the controls.The genetic polymorphism of TNF-α does not seem to be associated with asthma in Pakistani population.
کلیدواژه‌های انگلیسی مقاله Asthma,Pakistani population,TNF alpha 308
نویسندگان مقاله نصرت صبا | nusrat saba
institute of biomedical and genetic engineering, islamabad, pakistan and department of biochemistry, pirmehar ali shah arid agriculture university rawalpindi, pakistan


عثمان یوسف | osman yusuf
the allergy and asthma institute of pakistan, islamabad, pakistan


sadia رحمانی | sadia rehman
institute of biomedical and genetic engineering, islamabad, pakistan


سعیدا منیر | saeeda munir
institute of biomedical and genetic engineering, islamabad, pakistan


naghman بشیر | naghman bashir
chest and medical specialist, medicsi, islamabad, pakistan


atika منصور | atika mansoor
institute of biomedical and genetic engineering, islamabad, pakistan


ghazala رجا kaukab | ghazala raja kaukab
department of biochemistry, pirmehar ali shah arid agriculture university rawalpindi, pakistan
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/569
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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