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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۳، صفحات ۲۳۳-۲۴۵
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عنوان انگلیسی Human Leukocyte Antigens Influence the Antibody Response to Hepatitis B Vaccine
چکیده انگلیسی مقاله Hepatitis B virus (HBV) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world. The WHO strategy for effective control of HBV infection and its complications is mass vaccination of neonates and children within the framework of Expanded Programme on Immunization (EPI). Vaccination with hepatitis B surface antigen (HBsAg) induces protective antibody response (anti-HBs ≥ 10 IU/L) in 90-99% of vaccinees.The lack of response to HBsAg has been attributed to a variety of immunological mechanisms, including defect in antigen presentation, defect in HBsAg-specific T and/or B cell repertoires, T-cell suppression, increase in the regulatory T cell count, lack of necessary help of T-cells for production of anti-HBs by B cells, defect in Th1 and/or Th2 cytokine production and selective killing of HBsAg-specific B-cells by human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes. The HLA complex plays an important role in many of these immunological processes.A variety of HLA class I, II, and III alleles and antigens have been reported to beassociated with antibody response to HBsAg vaccination in different ethnic populations. Moreover, some HLA haplotypes were also associated with responsiveness to HBsAg.In this review the association of the HLA specificities with antibody response to hepatitis B (HB) vaccine is discussed.
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نویسندگان مقاله عبدالله جعفرزاده | abdollah jafarzadeh
molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran and department of immunology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran and department of immunology, school of medicine, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

معصومه باقری جامه بزرگی | masoome bagheri jamebozorgi
department of immunology, school of medicine, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

مریم نعمتی | maryam nemati
department of immunology, school of medicine, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

فروغ golsaz شیرازی | forough golsaz shirazi
department of immunology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاضل شکری | fazel shokri
department of immunology, school of public health, tehran university of medical sciences, tehran, iran and monoclonal antibody research center, avicenna research institute, acecr, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/563
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نوع مقاله منتشر شده Review Article(s)
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