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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۴، صفحات ۳۹۲-۴۰۱
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عنوان انگلیسی Effect of Influenza Virus Infection in a Murine Model of Asthma
چکیده انگلیسی مقاله Respiratory virus infection is a major cause of asthma exacerbation. However, the underlying mechanisms of this exacerbation are unknown. Therefore, to determine the mechanisms, we examined the effect of influenza infection in a murine model of asthma.Mice were divided into four groups: the phosphate-buffered saline (PBS), house dust mite (HDM), influenza, and HDM/influenza groups. The influenza group and the HDM/influenza group were infected with influenza A virus. We measured airway resistance (Penh value), examined the lung tissue for pathology, and analyzed the cells and cytokines in bronchoalveolar lavage fluid (BALF) by ELISA.At 50 mg/mL methacholine, the HDM/influenza group showed a significantly higher Penh value than the PBS, HDM, and influenza groups. The number of neutrophils in BALF was higher in the HDM/influenza group than in the HDM group. A significantly greater number of lymphocytes and macrophages were detected in the HDM/influenza group than in the HDM group. IFN-γ and IL-1β levels were higher in the HDM/influenza group than in the HDM group. IL-5 levels did not vary between the HDM and HDM/influenza groups, IL-10 was significantly lower in the HDM/influenza than in the HDM group. Chemokine (C-X-C motif) ligand 1 (CXCL1) and regulated upon activation, normal T cell expressed and secreted (RANTES) were higher in the HDM/influenza group than in the HDM group.In a murine model of asthma, influenza-induced airway inflammation appeared to becaused by simultaneous activation of neutrophilic and eosinophilic inflammation.
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نویسندگان مقاله hs کیم | hs kim
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


h lee | h lee
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


sulmui won | sulmui won
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


ek lee | ek lee
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


kyongwon bang | kyongwon bang
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


yh chun | yh chun
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


jongseo yoon | jongseo yoon
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


hh کیم | hh kim
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.


جین tack کیم | jin tack kim
department of pediatrics, college of medicine, the catholic university of korea, seoul, republic of korea.
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/586
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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