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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۴، شماره ۴، صفحات ۳۸۶-۳۹۱
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عنوان انگلیسی Association between Interleukin-23 Receptor R381Q Gene Polymorphism and Asthma
چکیده انگلیسی مقاله The SNP (rs11209026, Arg381Gln, R381Q) in the IL-23 receptor (IL23R) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. We, therefore, investigated the association between IL-23 R R381Q gene polymorphism and asthma.This case-control study was performed on 209 patients, and 200 healthy controls. Using PCR-RFLP, the R381Q variant was screened in the IL-23R gene of the patients and controls.Serum IgE levels were measured using ELISA technique. Eosinophil absolute count was done with Sesmex cell counter.Our results indicated that the genotype and allele frequencies of the IL-23R R381Q polymorphism is significantly different between asthmatic patients and control subjects (p< 0.001; odd ratio= 0.266; 95%, CI=0.118-0.604. Moreover, the asthmatic patients had higher eosinophil count and total serum IgE levels than controls as expected (p< 0.001).The present study suggested that R381Q polymorphism in IL-23 receptor may be a predisposing allele for asthma.
کلیدواژه‌های انگلیسی مقاله Asthma,IL-23 Receptor,Single Nucleotide Polymorphism
نویسندگان مقاله علی مسیبیان | ali mosayebian
department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مزدک گنجعلیخانی حاکمی | mazdak ganjalikhani hakemi
cellular and molecular immunology research center, faculty of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

رضوان مشکات | rezvan meshkat
department of immunology, faculty of medicine, shahrekord university of medical sciences, shahrekord, iran.


رامین قاسمی | ramin ghasemi
department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

حسین خان احمد | hossain khan ahmad
department of genetics and molecular biology, faculty of medicine, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مرتضی صمدی | morteza samadi
department of immunology, faculty of medicine, shahid sadoughi university of medical sciences, yazd, iran and reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, iran.
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/585
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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