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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۵، شماره ۱، صفحات ۲۰-۲۶
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عنوان انگلیسی Increase in mRNA Level of Orexin1 and 2 Receptors Following Induction of Experimental Autoimmune Encephalomyelitis in Mice
چکیده انگلیسی مقاله Orexin A and B are hypothalamic peptides with a wide variety of effects such as anti-inflammation and neuroprotection. Impaired function of orexin system has been reported in some neurodegenerative diseases like Parkinson, Huntington and Alzheimer. In this study, the mRNA expression levels of some hypothalamic peptides were investigated in C57BL/6 female mice with experimental autoimmune encephalomyelitis (EAE). Animals were randomly divided into two control and EAE groups. EAE was induced by administration of myelin oligodendrocyte glycoprotein (MOG) with complete Ferund’s adjuvant and pertussis toxin. Twenty-first days following immunization, mice were decapitated to remove the brains. Then, the expression profiles of prepro-orexin, orexin 1 receptors (OX1R) and orexin 2 receptors (OX2R) in hypothalamic region were assessed using real-time PCR method. In this study, we found a considerable increase in the mRNA expression of OX1R and OX2R following EAE induction in C57BL/6 mice. Elevation levels of OX1R and OX2R following EAE induction suggest that alteration in orexinergic system may involve in pathogenesis of multiple sclerosis.
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نویسندگان مقاله ایمان فاطمی | iman fatemi
department of pharmacology, school of medicine and razi drug research center, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

علی شمسی زاده | ali shamsizadeh
physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

علی روحبخش | ali roohbakhsh
pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فاطمه ایوبی | fatemeh ayoobi
geriatic care research center, rafsanjan university of medical sciences, rafsanjan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)

محمد حسین صنعتی | mohammad hossein sanati
department of medical genetics, national institute for genetic engineering and biotechnology, tehran, iran


منیژه متولیان | manijeh motevalian
department of pharmacology, school of medicine and razi drug research center, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/644
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زبان مقاله منتشر شده en
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