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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۵، شماره ۱، صفحات ۱۳-۱۹
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عنوان انگلیسی Effect of Vitamin A Supplementation on fatigue and depression in Multiple Sclerosis patients: A Double-Blind Placebo-Controlled Clinical Trial
چکیده انگلیسی مقاله Decreasing the population and activation of inflammatory T helper cells in multiple sclerosis (MS) patients using vitamin A derivatives (retinoic acids) has been well documented. The present study determined the effect of vitamin A supplementation on psychiatric signs in MS patients. The subjects were 101 relapsing-remitting MS patients enrolled in a placebo-controlled randomized clinical trial. The treatment group was administered 25000 IU/d retinyl palmitate (RP) for 6 months followed by 10000 IU/d RP for another 6 months. The results for baseline characteristics, modified fatigue impact scale and Beck Depression Inventory-II were recorded at the beginning and end of the one-year study. The non-normal distribution data was compared between groups using a nonparametric test and normal distribution data was analyzed using a parametric test. (ClinicalTrials.gov Identifiers: NCT01417273). The results showed significant improvement in the treatment group for fatigue (p=0.004) and depression (p=0.01). Vitamin A supplementation helped during interferon therapy in the treatment process and improved psychiatric outcomes for anti-inflammatory mechanisms.
کلیدواژه‌های انگلیسی مقاله Depression,Fatigue,Multiple sclerosis,Vitamin A
نویسندگان مقاله سما بیطرفان | sama bitarafan
department of neurology, iranian center of neurological research, neuroscience institute, imam khomeini hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی اکبر صبور یراقی | aliakbar saboor yaraghi
department of molecular and cellular nutrition, school of nutrition and dietetics, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد علی صحراییان | mohammad ali sahraian
department of neurology, sina ms research center, neuroscience institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

دانش سلطانی | danesh soltani
department of neurology, iranian center of neurological research, neuroscience institute, imam khomeini hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهریار نفیسی | shahriar nafissi
department of neurology, iranian center of neurological research, neuroscience institute, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

منصوره تقای | mansoureh togha
department of neurologyو sina ms research center, neuroscience institute, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ناهید بلادی مقدم | nahid beladi moghadam
department of neurology, imam hossein hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

تینا روستایی | tina roostaei
department of neurology, iranian center of neurological research, neuroscience institute, tehran university of medical sciences, imam khomeini hospital, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نیاز محمدزاده هنرور | niyaz mohammadzadeh honarvar
department of molecular and cellular nutrition, school of nutrition and dietetics, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد حسین حریرچیان | mohammad hossein harirchian
department of neurology,iranian center of neurological research, neuroscience institute, tehran university of medical sciences, imam khomeini hospital, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/692
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زبان مقاله منتشر شده en
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