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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۵، شماره ۴، صفحات ۲۷۵-۲۸۲
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عنوان انگلیسی Trefoil Factor Family 1 Is Involved in Airway Remodeling of Mustard Lung
چکیده انگلیسی مقاله Human airway is generally destructed by inhaled factors and is the barrier to the external environment and has a crucial role in protection of the internal homeostasis of the lung. Sulfur mustard (SM) is a chemical warfare that capable of producing severe chemical injuries primarily in the lungs. Trefoil factor family (TFFs) plays major roles in epithelial repair and homeostasis, particularly in the lung. This study attempted to verify the role of TFFs in airway that induced by sulfur mustard. Fifteen patients exposed to SM and 10 non-exposed subjects were enrolled in this study. Bronchoscopy was carried out and endobronchial biopsy specimens were taken. The TFFs gene expressions were evaluated by RT-PCR. The results revealed that the TFF1 was overexpressed in exposed subjects in comparison to non-exposed subjects. In conclusion, TFF1 displays a distinct protein expression pattern in the developing of airway remodeling due to SM inhalation and plays an important role in maintaining the airway epithelium function.
کلیدواژه‌های انگلیسی مقاله Airway remodeling,Sulfur mustard,Trefoil factor family
نویسندگان مقاله محمد رضا نورانی | mohammad reza nourani
genomic division, systems biology institute, chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

زهرا فرج پور | zahra farajpour
genomic division, systems biology institute, chemical injuries research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

علی نجفی | ali najafi
molecular biology research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

عباس علی ایمانی فولادی | abbas ali imani fooladi
applied microbiology research center, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/715
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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