| چکیده انگلیسی مقاله |
Introduction: Air pollution is a serious health concern worldwide, accounting for high premature morbidity and mortality annually. In this article, we explain the framework of a series of interrelated researches for studying particulate matter (PM10, PM < 10 μm) health impacts from dust storm and non-dust storm conditions in Tehran, Iran. Materials and methods: PM10 samples will be collected daily from two representative stations simultaneously during normal and dusty days by high volume samplers. PM chemical properties including ions, polycyclic aromatic hydrocarbons, metal (loid)s and oxidative potential will be analyzed. For in vitro biological toxicity, cytokine release from peripheral blood mononuclear cells and A549 cell line will be assayed. Also, DNA damage on A549 cell line will be examined using comet assay. In addition, DNA methylation of PBMCs and hemolysis of red blood cells (RBCs) will be accomplished. In a parallel panel study, after completing demographic and the International Study of Asthma and Allergies in Childhood (ISSAC) questionnaires, two groups of students will be selected. The exhaled breath condensate will be conducted to measure TNF-α, 8-IP, IL-6. Conclusions: This study aimed to evaluate the components, oxidative potential and biological effects induced by PM. Our research will be provided information on the toxicity potential of PM related to dust storm and traffic to help policy makers to establish strategies and prioritize resource allocation in comprehensive plan for PM control. |
| نویسندگان مقاله |
کاظم ندافی | kazem naddafi
center for air pollution research capr , institute for environmental research ier , tehran university of medical sciences, tehran, iran and department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
زهرا عطافر | zahra atafar
environmental health engineering department, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
مریم فرجی | maryam faraji
environmental health engineering department, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
مریم قنبریان | maryam ghanbarian
department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سهیلا رضایی | soheila rezaei
department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran and tuberculosis and lung disease research center, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
محمد قنبری قوزیکلی | mohammad ghanbari ghozikali
center for air pollution research capr , institute for environmental research ier , tehran university of medical sciences, tehran, iran and department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
محمد صادق حسنوند | mohammad sadegh hassanvand
immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
زهرا پورپاک | zahra pourpak
center for air pollution research capr , institute for environmental research ier , tehran university of medical sciences, tehran, iran and department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
علیرضا مصداقی نیا | alireza mesdaghinia
department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
مسعود یونسیان | masoud yunesian
environmental health engineering department, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
کامیار یغماییان | kamyar yaghmaeian
department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
رامین نبی زاده نودهی | ramin nabizadeh nodehi
department of immunology, school of medicine, tehran university of medical sciences, tehran, iran and department of research methodology and data analysis, institute for environmental research, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
محمد حسین نیکنام | mohammad hossein nicknam
department of environmental health engineering, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
میرزمانی زمان زاده | mirzaman zamanzadeh
department of research methodology and data analysis, institute for environmental research, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
منصور شمسی پور | mansour shamsipour
tuberculosis and lung disease research center, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
خلیل انصارین | khalil ansarin
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