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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۶، شماره ۴، صفحات ۲۸۲-۲۸۸
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عنوان انگلیسی Immunoglobulin Free Light Chains in the Pathogenesis of Lung Disorders
چکیده انگلیسی مقاله Inflammation is an important component of numerous cancers and chronic diseases and many inflammatory mediators have been shown to have potential prognostic roles. Tumor-infiltrating mast cells can promote tumor growth and angiogenesis, but the mechanism of mast cell activation is unclear. Early studies have shown that immunoglobulin free light chains (FLC) can trigger mast cell activation in an antigen-specific manner. Increased expression of FLC is observed within the stroma of many human cancers including those of breast, colon, lung, pancreas, kidney, and skin. These overexpressed FLCs are co-localized to areas of mast cell infiltration. Importantly, FLC expression is associated with basal-like cancers with an aggressive phenotype. Moreover, FLC is expressed in areas of inflammatory cell infiltration and its expression is significantly associated with poor clinical outcome. In addition, serum and bronchoalveolar fluid FLC concentrations are increased in patients with idiopathic pulmonary fibrosis (IPF) and hypersensitivity pneumonitis (HP) compared to control subjects. In this review, we provide an update on the role of FLC in the pathogenesis of several lung disorders and indicate how this may contribute to new therapeutic opportunities.
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نویسندگان مقاله اسماعیل مرتاض | esmaeil mortaz
cell and molecular biology group, airways disease section, national heart and lung institute, imperial college london, london, uk and priority research centre for healthy lungs, hunter medical research institute, the university of newcastle, newcastle, new south wales, australia


یان m adcock | ian m adcock
chronic respiratory disease research center shahid beheshti university of medical sciences, tehran, iran and national research institute of tuberculosis and lung diseases nritld , masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

حمیدرضا جماعتی | hamidreza jamaati
chronic respiratory disease research center shahid beheshti university of medical sciences, tehran, iran and national research institute of tuberculosis and lung diseases nritld , masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

عدنان خسروی | adnan khosravi
department of pathology and laboratory medicine, university of california, los angeles ucla , usa


مسعود موثقی | masoud movassaghi
division of pharmacology, utrecht institute for pharmaceutical sciences, faculty of science, utrecht university, utrecht, the netherlands and nutricia research centre for specialized nutrition, utrecht, the netherlands


johan garssen | johan garssen
chronic respiratory disease research center shahid beheshti university of medical sciences, tehran, iran and national research institute of tuberculosis and lung diseases nritld , masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مصطفی علوی مقدم | mostafa alavi mogadam
division of pharmacology, utrecht institute for pharmaceutical sciences, faculty of science, utrecht university, utrecht, the netherlands


فرانک a redegeld | frank a redegeld


نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/1082
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/89/article-89-430435.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article(s)
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