این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Microbiology، جلد ۱۸، شماره ۱، صفحات ۷۴-۸۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The antimicrobial effects of cord blood-derived platelet gel on nosocomial pathogens
چکیده انگلیسی مقاله Background and Objectives: Umbilical cord blood-derived platelet gel (CBPG) is rich in growth factors (GFs) and antimicrobial peptides. This study evaluated its in vitro antibacterial and antifungal activity against dominant nosocomial pathogens. Materials and Methods: In this experimental study, CB samples were taken from 12 healthy pregnant women post-cesarean at Motahari Hospital, Jahrom. Platelet -rich plasma (PRP) was isolated using a two-step centrifugation protocol (soft-spin: 200×g, 10 min; hard spin:1000×g, 15 min, 22°C) and activated with calcium and human thrombin to form PG. Antimicrobial effect of PG was determined against Klebsiella pneumoniae, Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, Pseudomonas aeruginosa, Candida albicans, Aspergillus spp., and Penicillium spp. using broth microdilution and time-kill assays per CLSI guidelines. Results: PG exhibited strong bacteriostatic activity against MRSA and K. pneumoniae (MIC 2.2–2.8 × 10⁸ platelets/mL; 1.7-1.8 log₁₀ reduction at 24 h, p < 0.001), while PRP was moderately active and PPP was ineffective. No significant activity was observed against P. aeruginosa or A. baumannii (p= 0.2). PG showed sustained fungistatic effects (MIC: 1.9-4.2× 10⁸ platelets/mL up to 72 h). Conclusion: CBPG exhibits potent bacteriostatic and fungistatic effects, particularly against MDR Gram-positive bacteria, offering a novel autologous antimicrobial.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Akbar Hashemi Tayer
Noncommunicable Diseases Research Center, Jahrom University of Medical Sciences, Jahrom, Iran


| Gholamreza Shokoohi
Department of Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/4789
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات