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Iranian Journal of Microbiology، جلد ۱۸، شماره ۱، صفحات ۴۸-۵۴
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عنوان انگلیسی Chromosome-borne blaCTX-M-65 gene in non-O1/O139 Vibrio cholerae isolated from bile
چکیده انگلیسی مقاله Background and Objectives: Non-O1/O139 Vibrio cholerae (NOVC) has been associated with extraintestinal infections; however, its isolation from bile remains exceedingly rare. This study reports the identification and comprehensive analysis of a NOVC strain isolated from bile, including its antimicrobial resistance profile, virulence gene content, and molecular characteristics. Materials and Methods: A NOVC isolate was obtained from the bile of a patient with a hepatobiliary tumor. The isolate was identified and subjected to antimicrobial susceptibility testing. Whole-genome sequencing was performed to characterize its molecular features, including antimicrobial resistance genes, virulence genes, and relevant genetic mutations. Results: The NOVC isolate presents a multi-drug resistance phenotype. Corresponding genomic analysis indicates that this strain belongs to a novel sequence type (ST1736), carrying various drug resistance genes and virulence factors. Moreover, the blaCTX-M-65 extended-spectrum β-lactamase (ESBL) gene was detected in its chromosomal genome. Conclusion: This study presents the first report of a multidrug-resistant NOVC strain isolated from bile in mainland China. Notably, the ESBL gene blaCTX-M-65 was identified chromosomally in NOVC for the first time.
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نویسندگان مقاله | Haifeng Mao
Department of Clinical Laboratory, The First Affiliated Hospital of Kangda College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China


| Xinzhe Wu
Department of Clinical Laboratory, The First Affiliated Hospital of Kangda College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China


| Danting Jin
Department of Clinical Laboratory, The First Affiliated Hospital of Kangda College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5322
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