این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Frontiers in Biomedical Technologies، جلد ۱۲، شماره ۱، صفحات ۱۱۶-۱۲۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Assessment of Morphological Changes in Breast Cancer Cells Following X-Ray Radiation Utilizing Digital Holographic Microscopy
چکیده انگلیسی مقاله Purpose: Digital holographic microscopy, being a label-free and entirely non-invasive technique, proficiently facilitates the quantitative assessment of morphological alterations in living cells. The primary objective of this investigation is to scrutinize the capability of a digital holographic microscope in assessing the morphological transformations of cancer cells exposed to X-ray radiation. Materials and Methods: The Michigan Cancer Foundation-7 (MCF7) cell line underwent exposure to X-ray radiation, administered in a singular fraction at a dose of 2 Gy. Subsequently, the MCF7 cell group was subjected to imaging through a digital holographic microscope. To scrutinize the morphological alterations between the radiation-exposed and control groups, the pertinent image parameters were extracted through the three-dimensional reconstruction of the microscopic images. Results: The results indicate a significant increase in the morphological parameters of cells, encompassing volume, and roughness, subsequent to radiation exposure when contrasted with the control group. This observation signifies discernible alterations in the shape and roughness characteristics of MCF7 cells. Conclusion: By extracting various parameters and broadening the spectrum of morphological and physical attributes, it becomes feasible to establish a more precise correlation between cellular conditions and the response to treatment. Such investigations pave the way for a more intricate exploration of cell morphology, enabling the identification of more specific parameters and distinctions in cellular response.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Zeinab Hormozi-Moghaddam
Iran university of medical sciences


| Seyedeh Mona Taheri
Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran


| Reza Paydar
Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran


| Ali Neshasteh-Riz
Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran


| Vahideh Farzam Rad
Department of Physics, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran


| Mohadeseh Shaghaghi
Department of Physics, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran
نشانی اینترنتی https://fbt.tums.ac.ir/index.php/fbt/article/view/880
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات