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Iranian Journal of Allergy, Asthma and Immunology، جلد ۲۲، شماره ۳، صفحات ۲۸۱-۲۸۹
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عنوان انگلیسی Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice
چکیده انگلیسی مقاله Ziziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were randomly assigned to receive intraperitoneal treatments of saline, dexamethasone (2 mg/kg), and 100 and 200 mg/kg of Z.J extracts, respectively. 24 h after intratracheal administration of LPS, bronchoalveolar lavage fluid and lung tissues were harvested and assessed for inflammatory cell influx, tumor necrosis factor-α (TNF-α) levels, and histological assessments. Treatment with Z.J extracts (100 and 200 mg/kg) and dexamethasone effectively reduced LPS-induced neutrophil and other inflammatory cell influx into the lung tissue compared to the untreated group. additionally, both doses of Z.J extracts (100 and 200 mg/kg) significantly ameliorated the lung wet-to-dry ratio and histopathological damage. Furthermore, compared to the untreated ALI mice, Z.J extract at the highest dose could significantly reduce the TNF-α level.   The present findings indicated that Z.J could effectively ameliorate LPS-induced ALI inflammatory responses and might be considered a promising alternative therapy for the ALI phenotype.
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نویسندگان مقاله | Parastoo Shaban
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.


| Niloofar Honari
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran


| Nafiseh Erfanian
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran


| Mehran Hosseini
Department of Anatomical Sciences, Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Hossein Safarpour
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran


| Saeed Nasseri
Department of Molecular Medicine, Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
نشانی اینترنتی https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3558
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