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Frontiers in Biomedical Technologies، جلد ۱۰، شماره ۲، صفحات ۱۸۰-۱۸۷
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عنوان انگلیسی Comparison of Two Electrode Placement Methods in Transcranial Direct Current Stimulation for Parkinson's disease
چکیده انگلیسی مقاله Purpose:  Therapeutic electrical stimulation of deep brain structures, such as subthalamic nucleus and the globus pallidus , is widely accepted as a treatment tool for patients with Parkinson's disease (PD). Electrical stimulation of the cerebral cortex with electrodes or transcranial stimulation can increase motor function among PD patients. Methods:  The aim of the present study was to evaluate the effects of non-invasive cortical stimulation with simulation of transcranial direct current stimulation (tDCS) technique on parts of the basal ganglia among PD patients in MATLAB software. tDCS was simulated using two different electrode placement methods (anodal stimulation of the primary motor cortex (M1) and anodal stimulation of the dorsolateral prefrontal cortex (DLPFC)) and stimulation on the target region was evaluated. All simulations were performed using head MRI images of four people with PD.  The effectiveness of brain stimulation was also studied using a basal ganglia model in MATLAB software. considering the membrane potential of Globus Pallidus and Subthalamic Nucleus regions, The effectiveness of each electrode placement method was evaluated in the BG model. Results:  According to the results, direct current stimulation was propagated through electrodes placed on the scalp throughout the model. Also anodal stimulation of primary motor cortex (M1) had a better effect on globus pallidus and subthalamic nucleus than anodal stimulation of the dorsolateral prefrontal cortex (DLPFC). Conclusion:  However, the procedures for performing tDCS and invasive brain stimulation in Parkinson's disease are different, the results show that this treatment can be appropriate and improve motor function in patients with PD.
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نویسندگان مقاله | Mohammad Mahdi Moeini Kouchaksaraei
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Fereidoun Nowshiravan Rahatabad
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Ali Sheikhani
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
نشانی اینترنتی https://fbt.tums.ac.ir/index.php/fbt/article/view/455
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