| چکیده انگلیسی مقاله |
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder more common in autosomal recessive (AR) than X-linked in Iran. This study aimed to assess whether having a child with AR-CGD would increase the likelihood of the next child being affected by CGD. Ninety-one families with at least one child affected by AR-CGD entered this study. Out of the 270 children, 128 were affected by AR-CGD. We used a cross tab for the odds ratio (OR) calculation, in which exposure to a previously affected child and the next child’s status were evaluated. This study illustrated that the chances of having another child afflicted with AR-CGD are significantly increased if the previous child had AR-CGD (OR=2.77, 95% CI=1.35-5.69).Althoug h AR disorders affect 25% of each pregnancy, we showed that the chance that the next child would be affected by CGD, given that the previous child was affected, is 2.77 times greater than in families with a normal child. It is recommended to warn families with one or more affected children to evaluate the risk of CGD in their subsequent pregnancies with prenatal diagnosis. |
| نویسندگان مقاله |
| Seyedeh Zalfa Modarresi
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Shagayegh Tajik
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Mohsen Badalzadeh
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Reza Fazlollahi
Immuniology, Asthma & Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Massoud Houshmand
National Institute for Genetic Engineering and Biotechnology, Tehran, Iran
| Marzieh Maddah
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Zahra Alizadeh
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Nabavi
Department of Pediatrics, Hazrat Rasool Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Nasrin Bazargan
Department of Pediatrics, Faculty of Medicine, Kerman University of Medical Sciences. Kerman, Iran
| Masoud Movahedi
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran AND Department of Immunology and Allergy, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Zahra Pourpak
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
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