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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۰، شماره ۲، صفحات ۱۱۹-۱۲۲
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عنوان انگلیسی Associations between HLA-C Alleles and Definite Meniere's Disease
چکیده انگلیسی مقاله Both genetic and environmental factors seem to play role in the etiology of Meniere's disease (MD). Several genes may be involved in susceptibility of MD including Human Leukocyte Antigens (HLA). The associations between MD and HLA alleles have been previously studied in other populations and certain HLA alleles were shown to be predisposing. The aim of this study was to determine the association between HLA-C allele frequencies and definite MD in patients who refer to Amir-Alam otolaryngology tertiary referral center in Tehran. Patients  with  definite  MD  (N=22)  enrolled  according  to  the  diagnostic  criteria  of American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS). Cases with all 3 symptoms of MD (Vertigo, Tinnitus and lower frequency of sensory-neural hearing loss) were included and those with suspected MD were excluded from study. HLA-Cw allele frequencies  were  determined  in  patients  non-related  healthy  controls  (N=91)  using PCR -SSP. We found that the frequency of HLACw*04 was significantly higher in patients compared to the controls [P = 0.0015, OR; 20, 95% CI (3.7-196.9)]. Our results revealed that HLA-C is a genetic predisposing factor in definite MD in patients who refer to Amir-Alam otolaryngology tertiary referral center.
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نویسندگان مقاله | Mohammad-Taghi Khorsandi
Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Mahsa M. Amoli
Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran


| Hebatodin Borghei
Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Hamed Emami
Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran


| Parvin Amiri
Endocrinology and Metabolism Research Centre, Tehran University of Medical Sciences, Tehran, Iran


| Ali Amirzargar
Immunogenetics Lab, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran


| Nasrin Yazdani
Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijaai.tums.ac.ir/index.php/ijaai/article/view/300
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