| چکیده انگلیسی مقاله |
Introduction: To date, little is known about the clinical features of pediatric COVID-19 patients admitted to intensive care units (ICUs). Objective: Herein, we aimed to describe the differences in demographic characteristics, laboratory findings, clinical presentations, and outcomes of Iranian pediatric COVID-19 patients admitted to ICU versus those in non-ICU settings. Methods: This multicenter investigation involved 15 general and pediatrics hospitals and included cases with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection based on positive real-time reverse transcription polymerase chain reaction (RT-PCR) admitted to these centers between March and May 2020, during the initial peak of the COVID-19 pandemic in Iran. Results: Overall, 166 patients were included, 61 (36.7%) of whom required ICU admission. The highest number of admitted cases to ICU were in the age group of 1–5 years old. Malignancy and heart diseases were the most frequent underlying conditions. Dyspnea was the major symptom for ICU-admitted patients. There were significant decreases in PH, HCO3 and base excess, as well as increases in creatinine, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and potassium levels between ICU-admitted and non-ICU patients. Acute respiratory distress syndrome (ARDS), shock, and acute cardiac injury were the most common features among ICU-admitted patients. The mortality rate in the ICU-admitted patients was substantially higher than non-ICU cases (45.9% vs. 1.9%, respectively; p< 0.001). Conclusions: Underlying diseases were the major risk factors for the increased ICU admissions and mortality rates in pediatric COVID-19 patients. There were few paraclinical parameters that could differentiate between pediatrics in terms of prognosis and serious outcomes of COVID-19. Healthcare providers should consider children as a high-risk group, especially those with underlying medical conditions. |
| نویسندگان مقاله |
| Alireza Fahimzad
Pediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Iraj Sedighi
Department of Pediatric, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
| Neda Pak
Children Medical Centre of Excellence, Tehran University of Medical Sciences, Tehran, Iran
| Mitra Khalili
Radiology Department, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Mohammad Farahmand
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Reza Shokrollahi
Pediatric Medicine Research Center, Qom University of Medical Sciences, Qom, Iran
| Hosein Heydari
Pediatric Medicine Research Center, Qom University of Medical Sciences, Qom, Iran
| Zahra Movahedi
Pediatric Medicine Research Center, Qom University of Medical Sciences, Qom, Iran
| Anahita Sanaei Dashti
Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
| Fatemeh Cheraghali
Department of Pediatric, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
| Ahmad Shamsizadeh
Aboozar Children Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
| Mohammadreza Mirkarimi
Aboozar Children Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
| Mohsen Alisamir
Aboozar Children Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
| Houman Hashemian
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
| Jafar Soltani
Department of Pediatrics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
| Ali Hosseininasab
Infectious and Tropical Research Center, Kerman University of Medical Sciences, Kerman, Iran
| Abdolkarim Hamedi
Infection Control Hand & Hygiene Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Mohammad Sadegh Rezai
Pediatric Infectious Diseases Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
| Shirin Sayyahfar
Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
| Manijeh Kahbazi
Infectious Diseases Research Center, Arak University of Medical Sciences, Arak, Iran
| Aliakbar Abedini
Department of Pediatrics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
| Afsaneh Akhondzadeh
Infectious Disease Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran
| Hamid Reza Sherkatolabbasieh
Department of Pediatrics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
| Ali Akbar Razlansari
Department of Pediatrics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
| Mina Alibeik
Pediatric Infections Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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