این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Advanced Journal of Emergency Medicine، جلد ۶، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Antiemetic effect of ondansetron versus metoclopramide in nauseous isolated head trauma patients: a double-blind randomized clinical trial
چکیده انگلیسی مقاله Objective: As nausea is one of the most common annoying symptoms in isolated head trauma (IHT) and needs timely management to prevent further adverse outcomes, this study was performed to compare ondansetron and metoclopramide as therapeutic agents in nauseous IHT. Methods: This study was a double-blind clinical trial. Participants were patients visiting the ED with the chief complaint of nauseous IHT event. Group A received 10mg/2ml of metoclopramide and group B 4mg/2ml of ondansetron through slow intravenous (IV) injection. The primary outcome was the severity of nausea 20 minutes after the intervention based on the visual analogue scale (VAS) score. Results: A total of 130 patients participated in the study (65 in each group). The mean age was 30.5±20.5 years, and 73.1% of the participants were male. The decrease in the mean nausea severity scores was statistically significant in both group A (78.3±9.7 before vs. 29.8±16.8 mm after the intervention; P < 0.001) and group B (78.5±11.1 vs. 27.8±13.9 mm; P < 0.001). There was no significant difference between the mean nausea severity scores of groups A and B before the intervention (P = 0.93) or after it (P = 0.65). The decrease in the severity score of nausea was 48.5 mm in group A and 50.6 mm in group B, with no significant difference between the two groups (P = 0.63). Conclusion: Both Ondansetron and metoclopramide significantly reduced the severity of nausea in patients with mild IHT visiting ED but no treatment arm was superior. Both drugs showed good safety profiles.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Hossein Alimohammadi
Department of Emergency Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Hossein Partovinezhad
Department of Emergency Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Tehran, Iran


| Ehsan Aliniagerdroudbari
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Sepideh Babaniamansour
School of Medicine, Islamic Azad University of Tehran Medical Sciences, Tehran, Iran


| Effat Partovinezhad
Department of Emergency Medicine, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Tehran, Iran


| Majid Shojaee
Department of Emergency Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://fem.tums.ac.ir/index.php/fem/article/view/630
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات