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Iranian Journal of Allergy, Asthma and Immunology، جلد ۲۱، شماره ۵، صفحات ۵۳۷-۵۴۸
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عنوان انگلیسی Association of Gene Polymorphisms in CXC Chemokine Receptor 5 with Rheumatoid Arthritis Susceptibility
چکیده انگلیسی مقاله Rheumatoid arthritis (RA) is caused by complicated interactions between genes and the environment. CXC chemokine receptor 5 (CXCR5) is required for B and T follicular helper cell migration and humoral immunity generation. Therefore, this study aimed to assess whether polymorphisms of the CXCR5 gene are implicated in RA development and progression. This case-control study enrolled 285 RA patients and 291 healthy controls. The polymerase chain reaction-ligase detection reaction method was used to genotype rs630923, rs497916, rs3922, and rs676925 in the CXCR5 gene. Epidemiological, clinical, and laboratory data were collected retrospectively. The rs630923 A allele was associated with a higher risk of RA (AOR [adjusted odds ratio]=2.00, 95% confidence interval [CI] =1.14–3.53). However, in the RA group, the frequency of the rs497916 T allele was lower (AOR=0.69, 95% CI=0.51–0.93). Regarding rs3922, AG+GG genotype carriers were at a significantly lower risk for RA than AA genotype carriers (AOR=0.70, 95% CI=0.49–0.99). In the RA group, we found that the different genotypes were significantly associated with specific laboratory values, including rheumatoid factor, total bilirubin, total cholesterol, low-density lipoprotein cholesterol, and alkaline phosphatase. This is the first report indicating that CXCR5 polymorphisms were associated with RA susceptibility. These findings lead to a rising possibility of identifying RA-susceptible individuals based on genetic markers.
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نویسندگان مقاله | Zhenzhen Su
Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China


| Lin Chen
Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China


| Qian Niu
Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China


| Bin Yang
Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China


| Zhuochun Huang
Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
نشانی اینترنتی https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3390
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