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Iranian Journal of Microbiology، جلد ۱۴، شماره ۳، صفحات ۴۱۰-۴۱۶
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عنوان انگلیسی Prevalence of occult hepatitis B virus infection among the blood donors in Golestan province: cross-sectional study
چکیده انگلیسی مقاله Background and Objectives: Despite the increased sensitivity of screening tests, the HBV can be transmitted during the window period and occult hepatitis B infection. The purpose of this study was to evaluate HBV markers and prevalence of OBI among HBsAg negative blood donors in Golestan province. Materials and Methods: Anti-HBc (IgM and IgG), anti-HBs and anti-HBe tests on 4313 serum samples (HBsAg negative) were performed by ELISA method. Also, all samples for the presence of HBV- DNA were tested by using NAT methods. SPSS software and chi-square test were used for data analysis. Results: Of the 4313 samples, 384 (8.9%) sera were anti-HBc positive. Also, of 384 anti-HBc positive samples, 302 (78.65%) were anti-HBs positive and 152 (39.6%) were anti-HBe positive. Thirty-nine (0.90%) samples were anti-HBc positive, anti-HBs negative and anti-HBe negative. HBV-DNA was not detected in any of specimens. Conclusion: Based on the results of retesting the isolated anti-HBc samples that after one year recalling, had undetectable HBV-DNA and for the prevention of the decreasing of healthy blood donation (due to false positive anti-HBc) and preservation of the blood supplies; Individual Donor Nucleic Acid Testing (ID-NAT) along with the anti-HBc testing for the improving blood safety is recommended.
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نویسندگان مقاله | Asma Bahrami
Department of Microbiology, Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran


| Ali Akbar Pourfathollah
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Masoud Parsania
Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Hossein Mehrabi Habibabadi
Department of Microbiology, Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran


| Zohreh Sharifi
Department of Microbiology, Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/3365
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