| چکیده انگلیسی مقاله |
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) spread rapidly all over the world in late 2019 and caused critical illness and death in some infected patients. This study aimed at examining several laboratory factors, especially inflammatory and immunological mediators, to identify severity and mortality associated biomarkers. Ninety-three hospitalized patients with confirmed coronavirus disease 2019 (COVID-19) were classified based on disease severity. The levels of biochemical, hematological, immunological, and inflammatory mediators were assessed, and their association with severity and mortality were evaluated. Hospitalized patients were mostly men (77.4%) with an average (standard deviation) age of 59.14 (14.81) years. The mortality rate was significantly higher in critical patients (85.7%). Increased serum levels of blood sugar, urea, creatinine, uric acid, phosphorus, total bilirubin, serum glutamic-oxaloacetic transaminase, serum glutamic-oxaloacetic transaminase, lactic dehydrogenase, C-reactive protein, ferritin, and procalcitonin were significantly prevalent (p=0.002, p< 0.001, p< 0.001, p=0.014, p=0.047, p=0.003, p< 0.001, p< 0.001, p< 0.001, p< 0.001, P< 0.001, and p< 0.001, respectively) in COVID-19 patients. Decreased red blood cell, hemoglobin, and hematocrit were significantly prevalent among COVID-19 patients than healthy control subjects (p< 0.001 for all). Troponin-I, interleukin-6, neutrophil/lymphocyte ratio (NLR), procalcitonin, and D-dimer showed a significant association with the mortality of patients with specificity and sensitivity more than 60%. Age, sex, underlying diseases, blood oxygen pressure, complete blood count along with C-reactive protein, lactic dehydrogenase, procalcitonin, D-dimer, and interleukin-6 evaluation help to predict the severity and required management for COVID-19 patients. Further investigations are highly recommended in a larger cohort study for validation of the present findings. |
| نویسندگان مقاله |
| Tooba Ghazanfari
Immunoregulation Research Center, Shahed University, Tehran, Iran AND Simorgh Clinical Laboratory, Tehran, Iran
| Mohammad Reza Salehi
Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Saeed Namaki
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Jalil Arabkheradmand
Ahya Neuroscience Research Center, Tehran, Iran
| Abdolrahman Rostamian
Department of Rheumatology, Valiasr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Maryam Rajabnia Chenary
Simorgh Clinical Laboratory, Tehran, Iran
| Sara Ghaffarpour
Immunoregulation Research Center, Shahed University, Tehran, Iran
| Sussan Kaboudanian Ardestani
Department of Immunology, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
| Maryam Edalatifard
Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Mehdi Naghizadeh
Immunoregulation Research Center, Shahed University, Tehran, Iran AND Non-communicable diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
| Saeed Mohammadi
Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
| Maryam Mahloujirad
Simorgh Clinical Laboratory, Tehran, Iran
| Alireza Izadi
Department of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Hossein Ghanaati
Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Taghi Beigmohammadi
Department of Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Vodjgani
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Bentolhoda Mohammad Shirazi
Immunoregulation Research Center, Shahed University, Tehran, Iran
| Ensie Sadat Mirsharif
Immunoregulation Research Center, Shahed University, Tehran, Iran
| Alireza Abdollahi
Department of Pathology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Mostafa Mohammadi
Department of Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Hamid Emadi Kouchak
Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Seyed Ali Dehghan Manshadi
Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Mohammad Saber Zamani
Immunoregulation Research Center, Shahed University, Tehran, Iran
| Maedeh Mahmoodi Aliabadi
Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
| Davoud Jamali
Department of Immunology, Shahed University, Tehran, Iran
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