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Iranian Journal of Allergy, Asthma and Immunology، جلد ۲۰، شماره ۳، صفحات ۳۰۳-۳۱۳
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عنوان انگلیسی Investigation of rs531564 Polymorphism in the Primary MicroRNA-124 Gene in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: Association with Disease Susceptibility and Clinical Characteristics
چکیده انگلیسی مقاله MicroRNA-124 (miR-124) is known as an important regulator of the immune system and inflammatory response. Studies have reported that this miRNA is dysregulated in autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A functional analysis demonstrated that rs531564 (C>G) affects the biogenesis of primary microRNA transcript-124 (pri-miR-124) and changes the expression of mature miR-124. In the present study, for the first time, we intended to evaluate the possible association between rs531564 polymorphism with SLE and RA risk.  In this case-control study, 110 patients with SLE, 115 patients with RA, and 120 healthy subjects were enrolled to evaluate rs531564 genotypes with real-time polymerase chain reaction (PCR) high resolution melting method. Our findings demonstrated that frequency of GC genotype and G allele were considerably higher in the control group than RA patients, demonstrating that that GC genotype and G allele have a protective effect for healthy individuals (GC vs CC; OR: 0.29; 95%CI [0.12,0.67] and G vs C; OR: 0.42; 95%CI [0.23,0.78]). However, no significant correlation was confirmed between allele and genotype frequencies of rs531564 with SLE risk (p>0.05). However, the G allele in rs531564 polymorphism was associated with serum level of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-dsDNA antibody, C3, C4, and creatinine, and frequency of renal involvements in SLE patients (p< 0.05). Moreover, in RA patients, the G was correlated with lower concentration ESR and CRP (p< 0.001).  Our findings propose a considerable association between rs531564 polymorphism in the pri-miR-124 gene with susceptibility and clinical characteristics of RA and SLE in the Iranian population.
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نویسندگان مقاله | Mehdi Hassani
School of Medicine, Aja University of Medical Science, Tehran, Iran


| Mohammad Dehani
School of Medicine, Aja University of Medical Science, Tehran, Iran


| Maryam Zare Rafie
School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


| Emran Esmaeilzadeh
Fetal Health Research Center, Hope Generation Foundation, Tehran, Iran


| Saeideh Davar
Department of Epidemiology and Biostatistics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Bahram Pakzad
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran.


| Meysam Mosallaei
School of Medicine, Aja University of Medical Science, Tehran, Iran


| Seyyed Mohamad Hoseini
Department of Pediatric, Semnan University of Medical Sciences, Semnan, Iran


| Hadi Bayat
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran AND Medical Nano-Technology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohsen Soosanabadi
Department of Medical Genetics, Semnan University of Medical Sciences, Semnan, Iran
نشانی اینترنتی https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3190
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