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Acta Medica Iranica، جلد ۵۹، شماره ۵، صفحات ۲۵۹-۲۶۴
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عنوان انگلیسی Single Nucleotide Polymorphism rs2075876 in AIRE Gene Is a Strong Rheumatoid Arthritis Determinant
چکیده انگلیسی مقاله Rheumatoid arthritis (RA) is a progressive and common autoimmune disease with multifactorial etiology. Several pieces of research show that genetic factors play a major role in the incidence of RA. Several genome-wide association studies (GWAS) have identified the autoimmune regulator (AIRE) gene as one of the candidate loci. This gene encodes a transcription factor, which is involved in the presentation of self-antigens and negative selection of self-reactive T-cells in the thymus. Studies have indicated that single nucleotide polymorphisms (SNPs) in the AIRE gene can change the gene expression and/or function. In the present study, we assessed the possible association between SNP rs2075876 (intronic variant) in the AIRE gene with RA risk in the Iranian population. A case-control study using 56 RA patients and 58 control subjects was undertaken to evaluate rs2075876 genotypes using real-time PCR high resolution melting method (HRM). Logistic regression analysis demonstrates that homozygous AA and heterozygous AG genotypes compared with GG genotype increase the risk of RA (AA vs GG; OR= 16.43; 95%CI [5.33-50.71] and AG vs GG; OR= 3.21; 95%CI [1.22-8.45]). Also, individuals with allele A were more frequently affected with RA than subjects with G allele (OR= 5.81; 95%CI [3.28-10.30]). Furthermore, in the patient group, we found a significant correlation between erythrocyte sedimentation rate and C-reactive protein concentration with rs2075876 polymorphism (P< 0.05). Our findings propose a substantial correlation between rs2075876 polymorphism and RA risk.
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نویسندگان مقاله | Mansour Salesi
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.


| Elham Noormohamadi
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.


| Bahram Pakzad
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.


| Farzaneh Yousefisadr
Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Rasoul Salehi
Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/8421
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