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Iranian Journal of Neurology، جلد ۱۱، شماره ۱، صفحات ۱۶-۲۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Antigliadin antibody in sporadic adult ataxia.
چکیده انگلیسی مقاله Background: The most common neurologic manifestation of gluten sensitivity is ataxia, which accounts for up to 40% of idiopathic sporadic ataxia. Timing of diagnosis of gluten ataxia is vital as it is one of the very few treatable causes of sporadic ataxia and causes irreversible loss of Purkinje cells. Antigliadin antibody (AGA) of the IgG type is the best marker for neurological manifestations of gluten sensitivity. This study was conducted to measure the prevalence of gluten ataxia in a group of Iranian patients with idiopathic ataxia. Methods: For 30 patients with idiopathic cerebellar ataxia, a questionnaire about clinical and demographic data was completed. Serum AGA (IgA and IgG) and antiendomysial antibody (AEA) were assessed. Gluten ataxic patients underwent duodenal biopsy. Magnetic resonance imaging was done for all patients to see if cerebellar atrophy is present. Results: Only 2 patients had a positive IgG AGA (6.7%) who both had a positive AEA while none of them showed changes of celiac disease in their duodenal biopsies. Conclusion: Only presence of gastrointestinal symptoms and pursuit eye movement disorders were higher in patients with gluten ataxia.Prevalence of gluten ataxia in Iranian patients with idiopathic ataxia seems to be lower than most of other regions. This could be explained by small sample size, differences in genetics and nutritional habits and also effect of serologic tests in clinical versus research setting. Further researches with larger sample size are recommended.
کلیدواژه‌های انگلیسی مقاله Celiac Disease,Idiopathic Ataxia,Gluten Ataxia,Prevalence
نویسندگان مقاله یاسر حمیدیان | yaser hamidian
department of radiology, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

منصوره تقای | mansoureh togha
department of neurology, sina hospital, tehran university of medical sciences and iran neurological research center, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهریار نفیسی | shahriar nafisi
department of neurology, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهاب دولتشاهی | shahab dowlatshahi
department of gastroenterology, sina hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سوده رازقی جهرمی | soodeh razeghi jahromi
shefa neuroscience research center, tehran, iran

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

ناهید بلادی مقدم | nahid beladi moghadam
department of neurology, imam hossein hospital, beheshti university of medical sciences, tehran, iran


نوید نمازی | navid namazi
ministry of health and medical education, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

پروین تاجیک | parvin tajik
department of epidemiology, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مسعود ماجد | masoud majed
students’ scientific research center ssrc , tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهدی آلوش | mahdi aloosh
research development center of sina hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijnl.tums.ac.ir/index.php/ijnl/article/view/838
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Special Articles
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