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Frontiers in Biomedical Technologies، جلد ۱، شماره ۲، صفحات ۲۷-۲۷
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عنوان انگلیسی A Comparative Assessment of Dynamic and Conventional Thallium-201 SPECT Myocardial Perfusion Imaging: Monte Carlo Simulations and Case Studies
چکیده انگلیسی مقاله Purpose: Clinical myocardial perfusion SPECT is commonly performed using static imaging. Dynamic SPECT enables extraction of quantitative as well as relative perfusion information. We aimed to evaluate the ability of dynamic SPECT for regular perfusion assessment in comparison to conventional SPECT in the context of thallium-201.  Methods: Simulations were performed utilizing a 4D-NCAT phantom for a dual-head gamma camera via the SIMIND Monte-Carlo simulator. 64s acquisition time-frames were used to track these dynamic changes. Different summations of time-frames were performed to create each dataset, which were compared to a standard static dataset. In addition, the effect of different delay-times post-injection was assessed. Twenty-segment analysis of perfusion was performed via the QPS analyser. Dynamic data were subsequently acquired in clinical studies using simulation-optimized protocols.  Results: For different summations of time-frames, perfusion scores in the basal and mid regions revealed 14.4% and 7.3% increases in dynamic SPECT compared to conventional imaging, with maximum changes in the basal anterior, while the distal and apical segments did not show noticeable changes. Specifically, dynamic imaging including 4 to 6 time-frames yielded enhanced correlation (R=0.957) with conventional imaging, in comparision to the usage of less time frames. Greatest correlation with conventional imaging was obtained for post-injection delays of 320 to 448s (R=0.982 to R=0.988).  Conclusion: While dynamic SPECT opens up an important opportunity for quantitative assessment (e.g. via generation of kinetic parameters), it was shown to generate highly consistent perfusion information compared to established conventional imaging. Future work focuses on merging these two important capabilities.
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نویسندگان مقاله | Zohreh Shahpouri
Radiation Medicine Engineering Dept. Shahid Beheshti University, GC, Iran.


| Alireza Kamali-Asl
Radiation Medicine Engineering Dept. Shahid Beheshti University, GC, Iran.


| Ahmad Bitarafan-Rajabi
Cardiovascular Interventional Research Center; Department of Nuclear Medicine, Rajaei Cardiovascular, Medical & Research Center, Iran University of medical sciences, Iran.


| Jakir Hossain
Departments of Radiology & Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, USA.


| SeyedMohammad Entezarmahdi
Radiation Medicine Engineering Dept. Shahid Beheshti University, GC, Iran


| Samane Mohseni
Radiation Medicine Engineering Dept. Shahid Beheshti University, GC, Iran


| Nahid Yaghoobi
Department of Nuclear Medicine, Rajaei Cardiovascular, Medical & Research Center, Iran University of Medical Sciences, Iran.


| Arman Rahmim
Departments of Radiology & Radiological Science, Johns Hopkins University, School of Medicine, Baltimore, USA AND Departments of Electrical & Computer Engineering, Johns Hopkins University, School of Medicine, Baltimore, USA.
نشانی اینترنتی http://fbt.tums.ac.ir/index.php/fbt/article/view/27
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/2721/article-2721-1970223.pdf
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