| چکیده انگلیسی مقاله |
The widespread use of sulfur mustard (SM) as a chemical warfare agent in the past century has proved its long-lasting toxic effects. Despite a lot of research over the past decades on Iranian veterans, there are still major gaps in the SM literature. Transforming growth factor (TGF-β), a cytokine that affects many different cell processes, has an important role in the lungs of patients with some of chronic airway diseases, especially with respect to airway remodeling in mustard lung. Primary airway fibroblasts from epibronchial biopsies were cultured, and gene expression of TGF-β1, TGF-β2, TbR-I and TbR-II in fibroblasts of SM injured patients and controls were investigated. Expression of TGF-βs and receptors was measured by RT-PCR. Protein level of TGF-β1was surveyed by western blot. Our findings revealed that expression levels of TGF-β1, TGF-β2, TbR-I and TbR-II were upregulated in the airway fibroblasts of SM exposed patients in comparison with control samples. TGF-β1 expression was shown to be markedly increased in primary lung fibroblasts of chemically injured patients. Our novel data, suggested that over-expression of TGF-β molecule and receptors in primary airway fibroblasts of mustard gas injured patients may be involved in progression of airway remodeling of these patients. |
| نویسندگان مقاله |
| Monireh Sadat Mirzamani
Genomics Division, Systems Biology Institute, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran AND Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
| Mohammad Reza Nourani
Genomics Division, Systems Biology Institute, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
| Abbas Ali Imani Fooladi
Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
| Samad Zare
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
| Majid Ebrahimi
Genomics Division, Systems Biology Institute, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran AND Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Ube, Japan
| Samaneh Yazdani
Genomics Division, Systems Biology Institute, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran AND Department of Pathology, Tohoku University GraduateSchool of Medicine, Sendai, Japan
| Mostafa Ghanei
Genomics Division, Systems Biology Institute, Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
| Mohammad Hassan Karimfar
Department of Anatomy, Medical School, Ilam University of Medical Sciences, Ilam, Iran
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