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Iranian Journal of Allergy, Asthma and Immunology، جلد ۱۲، شماره ۴، صفحات ۳۹۱-۳۹۶
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عنوان انگلیسی IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients.
چکیده انگلیسی مقاله Interleukin-13 (IL-13) is known to be a key regulator in immunoglobulin E (IgE) synthesis, mucus hypersecretion and airway hyperresponsiveness. Single nucleotide polymorphisms in IL-13 are associated with allergic phenotypes in several ethnically diverse populations.This study was performed in 214 atopic patients (asthma n=108, allergic rhinitis n=106) and sex-matched healthy controls (n=120). Genotyping of IL-13 gene polymorphisms was performed using polymerase chain reaction-based restriction fragment length polymorphism method.A statistically significant association of the A-1512C polymorphism in IL13 gene was observed with atopy (p< 0.001; χ2=19.0). Upon stratification of the data into asthma and AR association was revealed with both asthma (p=0.01; χ2=8.80) and AR (p< 0.001; χ2=24.3) in Pakistani patients. Higher odds ratio (OR 95% CI) was observed for AR 3.42 (2.04-5.76) relative to asthma 2.40 (1.41-4.09) for the C allele compared to controls.In conclusion the study provides the evidence A-1512C polymorphisms in IL-13 is a risk factor for asthma and AR.
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نویسندگان مقاله | Micheal Shazia
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan&#xA0;AND Department of Ophthalmology, Radboud University Nijmegen Medical Centre; Nijmegen, Netherlands.


| Minhas Kanza
<p align=&quot;center&quot;>Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan.</p>


| Ishaque Mehwish
<p align=&quot;center&quot;>Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan.</p>


| Shabbir Irum
<p align=&quot;center&quot;>Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan.</p>


| Ahmed Farida
National Institute of Health, Islamabad, Pakistan.


| Ahmed Asifa
<p align=&quot;center&quot;>Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan.</p>
نشانی اینترنتی http://ijaai.tums.ac.ir/index.php/ijaai/article/view/487
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/89/article-89-1354700.pdf
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