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Iranian Journal of Neurology، جلد ۱۵، شماره ۲، صفحات ۸۰-۸۴
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عنوان انگلیسی Association between Ala379Val ‎polymorphism of lipoprotein-‎associated phospholipase ‎A2 and migraine without ‎aura in Iranian population
چکیده انگلیسی مقاله Background: Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. The aim of this study was to investigate the association of a migraine without aura and Ala379Val polymorphism of lipoprotein-associated phospholipase A2 (Lp-PLA2) gene in the Iranian population. Methods: In this study, 103 migraine patients and 100 healthy controls were enrolled. DNA samples were extracted and the Ala379Val polymorphism of Lp-PLA2 gene was investigated. To assess severity of a headache, patients filled out the headache impact test (HIT-6) and migraine severity (MIGSEV) questionnaires. Results: Allele V had significantly lower frequency in the case group than control subjects [P = 0.001, odds ratio (OR) = 0.25, confidence interval (CI): 0.15-0.40]. The frequency of migraine patients that were a carrier of V allele (V/V and A/V) was statistically significant lower than the control group (P = 0.003, OR = 2.39, CI: 1.35-4.23). There was no significant difference of alleles frequency between three grades of MIGSEV (P = 0.316). Furthermore, total HIT-6 score was not significantly different between different genotypes (P = 0.466). Conclusion: Our results showed that Ala379Val gene polymorphism of LP-PLA2 is associated with lower risk of migraine but not with severity of headaches in an Iranian population.
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نویسندگان مقاله | Faraidoon Haghdoost
Medical Student Research Center AND Physiology Research Center, Isfahan University of ‎Medical Sciences, Isfahan, Iran


| Mahsa Gharzi
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎


| Farough Faez
Pharmacy Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Elinaz Hosseinzadeh
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎


| Mohamadhasan Tajaddini
Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Laleh Rafiei
Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Fatemeh Asgari
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎


| Mahboobeh Banihashemi
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎


| Samaneh Sadat Masjedi
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎


| Alireza Zandifar
Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎


| Shaghayegh Haghjooy-Javanmard
Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی http://ijnl.tums.ac.ir/index.php/ijnl/article/view/883
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